Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.
Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol.
5-Hydroxytryptamine-2 antagonist increases human slow wave sleep. When treating agitated patients, many clinicians consider calming effects and true antipsychotic effects to be one in the same, which is not correct.
Expert Consensus Guideline Series Treatment of schizophrenia. Aripiprazole is a dopamine D2 partial agonist, serotonin 5HT1A partial agonist, and serotonin 5HT2A antagonist. Patients with acute exacerbation of psychosis often have insomnia and frequently report paranoia that “something” will happen to them while they sleep. Intramuscular aripiprazole for the treatment of acute agitation in patients with schizophrenia or schizoaffective disorder: a double-blind, placebo-controlled comparison with intramuscular haloperidol.
The authors suggested that cost appears to becoming a less issue, although atypical anti-psychotics are more expensive especially when new to the market. There were some limitations with the review some drugs are not currently used in the UK, others have a good evidence base underpinning them but not included in the analysis, for example, sulpiride and perphenazine.
Int J Neuropsychopharmacol 2002;5(suppl 1): S176.- 2. A meta-analysis of the efficacy of second-generation antipsychotics. Safety and tolerability: how do newer generation ”atypical” antipsychotics compare? If you initiate a more sedating antipsychotic acutely, switching to a less sedating agent when the patient is stable and the illness is in remission may support adherence and improve outcomes. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Two to 4 weeks is generally adequate, but some patients may need the adjunctive therapy for several months. Aripiprazole: a dopamine-serotonin system stabilizer [abstract no. Initiate the antipsychotic at or titrate to a reasonable, not overly high dose—such as: Continue the patient on that dose, and use a nonantipsychotic such as a benzodiazepine to help control insomnia, anxiety, and agitation. Int J Neuropsychopharmacol 2002;5(suppl 1): S176.- 2. A meta-analysis of the efficacy of second-generation antipsychotics.